Seroatlas · Human Serome Atlas

TMEM61

Transmembrane protein 61

Also known as: TMM61_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N0U2
Gene
TMEM61
Ensembl
ENSG00000143001
Chromosome
1
Canonical length
210 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q8N0U2|TMEM61
     1  MALPQMCDGS HLASTLRYCM TVSGTVVLVA GTLCFAWWSE GDATAQPGQL APPTEYPVPE
    61  GPSPLLRSVS FVCCGAGGLL LLIGLLWSVK ASIPGPPRWD PYHLSRDLYY LTVESSEKES
   121  CRTPKVVDIP TYEEAVSFPV AEGPPTPPAY PTEEALEPSG SRDALLSTQP AWPPPSYESI
   181  SLALDAVSAE TTPSATRSCS GLVQTARGGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 38 nTPM
  • salivary gland: 18 nTPM
  • kidney: 16 nTPM
  • parathyroid gland: 13 nTPM
  • cerebellum: 6.3 nTPM
  • adrenal gland: 4.7 nTPM

Single-cell type

  • respiratory ionocytes: 356 nCPM
  • salivary ionocytes: 219 nCPM
  • epididymal clear cells: 88 nCPM
  • corticotrophs: 71 nCPM
  • goblet cells: 64 nCPM
  • salivary duct cells: 54 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 6.8 nTPM
  • pons: 6.2 nTPM
  • hypothalamus: 3.6 nTPM
  • medulla oblongata: 3.3 nTPM
  • choroid plexus: 2.5 nTPM
  • midbrain: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0
gnomAD missense Z
0.19
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TMEM61 protein family
  • TMEM61 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM61 as an antibody target. Whether an autoantibody or antibody against TMEM61 could matter depends on whether native TMEM61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM61 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM61. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...