Seroatlas · Human Serome Atlas

TMEM60

Transmembrane protein 60

Also known as: C7orf35, DC32, TMM60_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2L4
Gene
TMEM60
Ensembl
ENSG00000135211
Chromosome
7
Canonical length
133 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>Q9H2L4|TMEM60
     1  MRMSLAQRVL LTWLFTLLFL IMLVLKLDEK APWNWFLIFI PVWIFDTILL VLLIVKMAGR
    61  CKSGFDPRHG SHNIKKKAWY LIAMLLKLAF CLALCAKLEQ FTTMNLSYVF IPLWALLAGA
   121  LTELGYNVFF VRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM60 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 37 nTPM
  • liver: 33 nTPM
  • kidney: 28 nTPM
  • epididymis: 28 nTPM
  • breast: 28 nTPM
  • lymph node: 27 nTPM

Single-cell type

  • oocytes: 106 nCPM
  • hofbauer cells: 105 nCPM
  • esophageal apical cells: 100 nCPM
  • platelets: 78 nCPM
  • cytotrophoblasts: 68 nCPM
  • kupffer cells: 68 nCPM

Immune cell

  • basophil: 210 nTPM
  • eosinophil: 101 nTPM
  • memory B-cell: 89 nTPM
  • T-reg: 80 nTPM
  • naive B-cell: 73 nTPM
  • intermediate monocyte: 59 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • hypothalamus: 14 nTPM
  • white matter: 14 nTPM
  • spinal cord: 13 nTPM
  • cerebellum: 12 nTPM
  • pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.75
gnomAD missense Z
0.42
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM60 as an antibody target. Whether an autoantibody or antibody against TMEM60 could matter depends on whether native TMEM60 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM60 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM60 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM60. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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