TMEM59L
Transmembrane protein 59-like
Also known as: BSMAP, C19orf4, TM59L_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UK28
- Gene
- TMEM59L
- Ensembl
- ENSG00000105696
- Chromosome
- 19
- Canonical length
- 342 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
OverviewNCBI Gene
This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
342 residues, UniProt reviewed canonical sequence.
>Q9UK28|TMEM59L
1 MAAVALMPPP LLLLLLLASP PAASAPSARD PFAPQLGDTQ NCQLRCRDRD LGPQPSQAGL
61 EGASESPYDR AVLISACERG CRLFSICRFV ARSSKPNATQ TECEAACVEA YVKEAEQQAC
121 SHGCWSQPAE PEPEQKRKVL EAPSGALSLL DLFSTLCNDL VNSAQGFVSS TWTYYLQTDN
181 GKVVVFQTQP IVESLGFQGG RLQRVEVTWR GSHPEALEVH VDPVGPLDKV RKAKIRVKTS
241 SKAKVESEEP QDNDFLSCMS RRSGLPRWIL ACCLFLSVLV MLWLSCSTLV TAPGQHLKFQ
301 PLTLEQHKGF MMEPDWPLYP PPSHACEDSL PPYKLKLDLT KLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM59L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 343 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 343 nTPM
- hypothalamus: 276 nTPM
- cerebellum: 243 nTPM
- hippocampal formation: 231 nTPM
- basal ganglia: 219 nTPM
- amygdala: 212 nTPM
Single-cell type
- other brain neurons: 247 nCPM
- brain excitatory neurons: 194 nCPM
- brain inhibitory neurons: 169 nCPM
- oligodendrocyte progenitor cells: 72 nCPM
- müller glia: 68 nCPM
- ependymal cells: 57 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 519 nTPM
- cerebral cortex: 507 nTPM
- basal ganglia: 430 nTPM
- hippocampal formation: 426 nTPM
- amygdala: 323 nTPM
- white matter: 297 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.85
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.9
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM59L as an antibody target. Whether an autoantibody or antibody against TMEM59L could matter depends on whether native TMEM59L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM59L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM59L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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