Seroatlas · Human Serome Atlas

TMEM54

Transmembrane protein 54

Also known as: BCLP, CAC-1, TMM54_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969K7
Gene: TMEM54
Ensembl: ENSG00000121900
Chromosome: 1
Canonical length: 222 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q969K7|TMEM54
     1  MCLRLGGLSV GDFRKVLMKT GLVLVVLGHV SFITAALFHG TVLRYVGTPQ DAVALQYCVV
    61  NILSVTSAIV VITSGIAAIV LSRYLPSTPL RWTVFSSSVA CALLSLTCAL GLLASIAMTF
   121  ATQGKALLAA CTFGSSELLA LAPDCPFDPT RIYSSSLCLW GIALVLCVAE NVFAVRCAQL
   181  THQLLELRPW WGKSSHHMMR ENPELVEGRD LLSCTSSEPL TL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 243 nTPM

Expression across tissuesHPA

Tissue

colon: 243 nTPM
esophagus: 137 nTPM
small intestine: 113 nTPM
duodenum: 109 nTPM
rectum: 106 nTPM
skin: 106 nTPM

Single-cell type

colonocytes: 1,522 nCPM
esophageal apical cells: 664 nCPM
enterocytes: 376 nCPM
enteric transient amplifying cells: 344 nCPM
foveolar cells: 335 nCPM
goblet cells: 315 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 45 nTPM
hypothalamus: 45 nTPM
midbrain: 42 nTPM
amygdala: 40 nTPM
spinal cord: 40 nTPM
cerebral cortex: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM54 as an antibody target. Whether an autoantibody or antibody against TMEM54 could matter depends on whether native TMEM54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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