Seroatlas · Human Serome Atlas

TMEM52B

Transmembrane protein 52B

Also known as: C12orf59, FLJ31166, TM52B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4KMG9
Gene
TMEM52B
Ensembl
ENSG00000165685
Chromosome
12
Canonical length
183 aa
Protein class
Predicted intracellular proteins
Subcellular location
Focal adhesion sites

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q4KMG9|TMEM52B
     1  MGVRVHVVAA SALLYFILLS GTRCEENCGN PEHCLTTDWV HLWYIWLLVV IGALLLLCGL
    61  TSLCFRCCCL SRQQNGEDGG PPPCEVTVIA FDHDSTLQST ITSLQSVFGP AARRILAVAH
   121  SHSSLGQLPS SLDTLPGYEE ALHMSRFTVA MCGQKAPDLP PVPEEKQLPP TEKESTRIVD
   181  SWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM52B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 106 nTPM
  • placenta: 4.6 nTPM
  • bone marrow: 3.2 nTPM
  • cerebral cortex: 1.7 nTPM
  • salivary gland: 1.2 nTPM
  • basal ganglia: 1 nTPM

Single-cell type

  • distal convoluted tubule cells: 1,015 nCPM
  • epicardial cells: 726 nCPM
  • renal connecting tubule cells: 307 nCPM
  • cytotrophoblasts: 61 nCPM
  • loop of henle epithelial cells: 59 nCPM
  • renal collecting duct intercalated cells: 35 nCPM

Immune cell

  • myeloid DC: 0.8 nTPM
  • basophil: 0.4 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • white matter: 4.2 nTPM
  • medulla oblongata: 3.4 nTPM
  • pons: 3.2 nTPM
  • thalamus: 3.2 nTPM
  • spinal cord: 3.1 nTPM
  • basal ganglia: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0
gnomAD missense Z
-0.31
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM52B as an antibody target. Whether an autoantibody or antibody against TMEM52B could matter depends on whether native TMEM52B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM52B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM52B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM52B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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