TMEM52
Transmembrane protein 52
Also known as: TMM52_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NDY8
- Gene
- TMEM52
- Ensembl
- ENSG00000178821
- Chromosome
- 1
- Canonical length
- 209 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
209 residues, UniProt reviewed canonical sequence.
>Q8NDY8|TMEM52
1 MARGPLAARG LRLLLPLLPL LPLLPLPQVA LGFADGSCDP SDQCPPQARW SSLWHVGLIL
61 LAVLLLLLCG VTAGCVRFCC LRKQAQAQPH LPPARQPCDV AVIPMDSDSP VHSTVTSYSS
121 VQYPLGMRLP LPFGELDLDS MAPPAYSLYT PEPPPSYDEA VKMAKPREEG PALSQKPSPL
181 LGASGLETTP VPQESGPNTQ LPPCSPGAPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 280 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 280 nTPM
- pancreas: 207 nTPM
- tongue: 194 nTPM
- adrenal gland: 51 nTPM
- testis: 29 nTPM
- salivary gland: 19 nTPM
Single-cell type
- thymic myoid cells: 116 nCPM
- pancreatic acinar cells: 95 nCPM
- early primary spermatocytes: 50 nCPM
- myonuclei: 46 nCPM
- oocytes: 46 nCPM
- differentiating spermatogonia: 41 nCPM
Immune cell
- plasmacytoid DC: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 4 nTPM
- cerebellum: 2.1 nTPM
- cerebral cortex: 2.1 nTPM
- midbrain: 2.1 nTPM
- basal ganglia: 2 nTPM
- hypothalamus: 1.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.38
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM52 as an antibody target. Whether an autoantibody or antibody against TMEM52 could matter depends on whether native TMEM52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...