Seroatlas · Human Serome Atlas

TMEM51

Transmembrane protein 51

Also known as: C1orf72, FLJ10199, TMM51_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NW97
Gene: TMEM51
Ensembl: ENSG00000171729
Chromosome: 1
Canonical length: 253 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9NW97|TMEM51
     1  MMAQSKANGS HYALTAIGLG MLVLGVIMAM WNLVPGFSAA EKPTAQGSNK TEVGGGILKS
    61  KTFSVAYVLV GAGVMLLLLS ICLSIRDKRK QRQGEDLAHV QHPTGAGPHA QEEDSQEEEE
   121  EDEEAASRYY VPSYEEVMNT NYSEARGEEQ NPRLSISLPS YESLTGLDET TPTSTRADVE
   181  ASPGNPPDRQ NSKLAKRLKP LKVRRIKSEK LHLKDFRINL PDKNVPPPSI EPLTPPPQYD
   241  EVQEKAPDTR PPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

pancreas: 43 nTPM
kidney: 32 nTPM
stomach: 28 nTPM
urinary bladder: 28 nTPM
duodenum: 21 nTPM
ovary: 20 nTPM

Single-cell type

urothelial cells: 372 nCPM
epididymal clear cells: 316 nCPM
renal connecting tubule cells: 305 nCPM
renal collecting duct intercalated cells: 293 nCPM
papillary tip epithelial cells: 193 nCPM
salivary ionocytes: 188 nCPM

Immune cell

non-classical monocyte: 0.9 nTPM
intermediate monocyte: 0.6 nTPM
classical monocyte: 0.5 nTPM
myeloid DC: 0.4 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 27 nTPM
medulla oblongata: 9.2 nTPM
white matter: 8.5 nTPM
thalamus: 8 nTPM
cerebral cortex: 7.7 nTPM
midbrain: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.3
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 51
Transmembrane protein 51

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM51 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM51 as an antibody target. Whether an autoantibody or antibody against TMEM51 could matter depends on whether native TMEM51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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