Seroatlas · Human Serome Atlas

TMEM50A

Transmembrane protein 50A

Also known as: SMP1, TM50A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95807
Gene: TMEM50A
Ensembl: ENSG00000183726
Chromosome: 1
Canonical length: 157 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>O95807|TMEM50A
     1  MSGFLEGLRC SECIDWGEKR NTIASIAAGV LFFTGWWIII DAAVIYPTMK DFNHSYHACG
    61  VIATIAFLMI NAVSNGQVRG DSYSEGCLGQ TGARIWLFVG FMLAFGSLIA SMWILFGGYV
   121  AKEKDIVYPG IAVFFQNAFI FFGGLVFKFG RTEDLWQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM50A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 77 nTPM
rectum: 62 nTPM
adrenal gland: 61 nTPM
colon: 55 nTPM
lung: 55 nTPM
placenta: 54 nTPM

Single-cell type

platelets: 1,153 nCPM
esophageal apical cells: 835 nCPM
extravillous trophoblasts: 461 nCPM
neutrophils: 327 nCPM
esophageal suprabasal cells: 307 nCPM
suprabasal keratinocytes: 273 nCPM

Immune cell

basophil: 276 nTPM
neutrophil: 159 nTPM
non-classical monocyte: 118 nTPM
eosinophil: 110 nTPM
total PBMC: 106 nTPM
T-reg: 96 nTPM

Brain region

white matter: 39 nTPM
basal ganglia: 34 nTPM
spinal cord: 33 nTPM
medulla oblongata: 33 nTPM
cerebral cortex: 31 nTPM
thalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.16
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

late endosome to vacuole transport via multivesicular body sorting pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM50A as an antibody target. Whether an autoantibody or antibody against TMEM50A could matter depends on whether native TMEM50A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM50A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM50A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...