TMEM45B
Transmembrane protein 45B
Also known as: BC016153, FLJ40787, TM45B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96B21
- Gene
- TMEM45B
- Ensembl
- ENSG00000151715
- Chromosome
- 11
- Canonical length
- 275 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to be involved in innate immune response. Predicted to be located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
275 residues, UniProt reviewed canonical sequence.
>Q96B21|TMEM45B
1 MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA AIRTLFSVTG
61 ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG IVDMLTYLVS HVPLGVDRLV
121 MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL LYALFGGCVS ISLEVIFRDH IVLELFRTSL
181 IILQGTWFWQ IGFVLFPPFG TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL
241 LTRMKRHGRG EIIGIQKLNS DDTYQTALLS GSDEELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM45B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 128 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 128 nTPM
- small intestine: 120 nTPM
- colon: 89 nTPM
- rectum: 89 nTPM
- esophagus: 64 nTPM
- urinary bladder: 29 nTPM
Single-cell type
- esophageal apical cells: 1,168 nCPM
- enterocytes: 466 nCPM
- colonocytes: 406 nCPM
- urothelial cells: 304 nCPM
- esophageal suprabasal cells: 264 nCPM
- tuft cells: 231 nCPM
Immune cell
- neutrophil: 12 nTPM
- naive CD4 T-cell: 3.6 nTPM
- memory CD4 T-cell: 3.1 nTPM
- basophil: 1.4 nTPM
- total PBMC: 0.9 nTPM
- memory CD8 T-cell: 0.8 nTPM
Brain region
- choroid plexus: 17 nTPM
- midbrain: 7.2 nTPM
- hippocampal formation: 5.2 nTPM
- hypothalamus: 5.1 nTPM
- cerebellum: 4.8 nTPM
- cerebral cortex: 4.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.25
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM45B as an antibody target. Whether an autoantibody or antibody against TMEM45B could matter depends on whether native TMEM45B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM45B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM45B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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