Seroatlas · Human Serome Atlas

TMEM45A

Transmembrane protein 45A

Also known as: DERP7, FLJ10134, TM45A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWC5
Gene: TMEM45A
Ensembl: ENSG00000181458
Chromosome: 3
Canonical length: 275 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q9NWC5|TMEM45A
     1  MGNFRGHALP GTFFFIIGLW WCTKSILKYI CKKQKRTCYL GSKTLFYRLE ILEGITIVGM
    61  ALTGMAGEQF IPGGPHLMLY DYKQGHWNQL LGWHHFTMYF FFGLLGVADI LCFTISSLPV
   121  SLTKLMLSNA LFVEAFIFYN HTHGREMLDI FVHQLLVLVV FLTGLVAFLE FLVRNNVLLE
   181  LLRSSLILLQ GSWFFQIGFV LYPPSGGPAW DLMDHENILF LTICFCWHYA VTIVIVGMNY
   241  AFITWLVKSR LKRLCSSEVG LLKNAEREQE SEEEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM45A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 449 nTPM

Expression across tissuesHPA

Tissue

skin: 449 nTPM
liver: 93 nTPM
vagina: 75 nTPM
cervix: 67 nTPM
tonsil: 48 nTPM
breast: 40 nTPM

Single-cell type

decidual stromal cells: 704 nCPM
suprabasal keratinocytes: 283 nCPM
early spermatids: 223 nCPM
conjunctival goblet cells: 175 nCPM
hepatocytes: 146 nCPM
late primary spermatocytes: 138 nCPM

Immune cell

classical monocyte: 0.9 nTPM
myeloid DC: 0.9 nTPM
total PBMC: 0.6 nTPM
plasmacytoid DC: 0.5 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

basal ganglia: 5.3 nTPM
choroid plexus: 3.2 nTPM
white matter: 2.6 nTPM
medulla oblongata: 2.3 nTPM
thalamus: 2.3 nTPM
midbrain: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM45A as an antibody target. Whether an autoantibody or antibody against TMEM45A could matter depends on whether native TMEM45A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM45A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM45A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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