Seroatlas · Human Serome Atlas

TMEM44

Transmembrane protein 44

Also known as: DKFZp686O18124, TMM44_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2T9K0
Gene: TMEM44
Ensembl: ENSG00000145014
Chromosome: 3
Canonical length: 475 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable basic amino acid transmembrane transporter activity. Predicted to be involved in basic amino acid transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q2T9K0|TMEM44
     1  MGEAPSPAPA LWDWDYLDRC FARHRVCISF GLWICASSCW IAAHALLLYL RCAQKPRQDQ
    61  SALCAACCLL TSLCDTVGAL LARQLTIQVF TGAYLAAIDL VNFMFILFPV CGSKFKSNSD
   121  REARERKRRR QLRASVFALA LPLSLGPCWA LWVAVPKASA TIRGPQRRLL ASLLQENTEI
   181  LGYLLGSVAA FGSWASRIPP LSRIAPPPTL GITTQHEIWR GQMSKPSQSP SRSPSGHWRA
   241  AAQRQVLGTE MCRGKTFPSI HLWTRLLSAL AGLLYASAIV AHDQHPEYLL RATPWFLTSL
   301  GRAALDLAII FLSCVMKSKM RQALGFAKEA RESPDTQALL TCAEKEEENQ ENLDWVPLTT
   361  LSHCKSLRTM TAISRYMELT IEPVQQAGCS ATRLPGDGQT SAGDASLQDP PSYPPVQVIR
   421  ARVSSGSSSE VSSINSDLEW DPEDVNLEGS KENVELLGSQ VHQDSVRTAH LSDDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

epididymis: 13 nTPM
basal ganglia: 11 nTPM
lung: 11 nTPM
colon: 11 nTPM
adipose tissue: 10 nTPM
heart muscle: 9.7 nTPM

Single-cell type

mast cells: 119 nCPM
vascular endothelial cells: 59 nCPM
lymphatic endothelial cells: 52 nCPM
epididymal principal cells: 46 nCPM
goblet cells: 44 nCPM
hematopoietic stem cells: 44 nCPM

Immune cell

NK-cell: 8.3 nTPM
basophil: 3.6 nTPM
memory CD8 T-cell: 0.6 nTPM
gdT-cell: 0.4 nTPM
neutrophil: 0.4 nTPM
non-classical monocyte: 0.4 nTPM

Brain region

basal ganglia: 13 nTPM
cerebral cortex: 12 nTPM
hypothalamus: 11 nTPM
hippocampal formation: 10 nTPM
pons: 9.5 nTPM
amygdala: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

basic amino acid transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Lysosomal/Vacuolar Amino Acid Transporter 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM44 as an antibody target. Whether an autoantibody or antibody against TMEM44 could matter depends on whether native TMEM44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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