Seroatlas · Human Serome Atlas

TMEM42

Transmembrane protein 42

Also known as: MGC29956, TMM42_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q69YG0
Gene
TMEM42
Ensembl
ENSG00000169964
Chromosome
3
Canonical length
159 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q69YG0|TMEM42
     1  MAERPGPPGG AVSATAYPDT PAEFPPHLQA GAMRRRFWGV FNCLCAGAFG ALAAASAKLA
    61  FGSEVSMGLC VLGIIVMAST NSLMWTFFSR GLSFSMSSAI ASVTVTFSNI LSSAFLGYVL
   121  YGECQEVLWW GGVFLILCGL TLIHRKLPPT WKPLPHKQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 35 nTPM
  • midbrain: 32 nTPM
  • hypothalamus: 32 nTPM
  • amygdala: 30 nTPM
  • hippocampal formation: 30 nTPM
  • basal ganglia: 29 nTPM

Single-cell type

  • thymocytes: 1.7 nCPM
  • myosatellite cells: 1.2 nCPM
  • endometrial secretory cells: 0.6 nCPM
  • late spermatids: 0.4 nCPM
  • hepatocytes: 0.3 nCPM
  • suprabasal keratinocytes: 0.3 nCPM

Immune cell

  • naive CD4 T-cell: 16 nTPM
  • memory B-cell: 15 nTPM
  • naive B-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • plasmacytoid DC: 13 nTPM
  • non-classical monocyte: 12 nTPM

Brain region

  • white matter: 11 nTPM
  • hypothalamus: 10 nTPM
  • spinal cord: 9.7 nTPM
  • basal ganglia: 9.6 nTPM
  • midbrain: 9.4 nTPM
  • thalamus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0.08
gnomAD missense Z
0.14
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM42 as an antibody target. Whether an autoantibody or antibody against TMEM42 could matter depends on whether native TMEM42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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