Seroatlas · Human Serome Atlas

TMEM41A

Transmembrane protein 41A

Also known as: MGC15397, TM41A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HV5
Gene: TMEM41A
Ensembl: ENSG00000163900
Chromosome: 3
Canonical length: 264 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q96HV5|TMEM41A
     1  MRPLLGLLLV FAGCTFALYL LSTRLPRGRR LGSTEEAGGR SLWFPSDLAE LRELSEVLRE
    61  YRKEHQAYVF LLFCGAYLYK QGFAIPGSSF LNVLAGALFG PWLGLLLCCV LTSVGATCCY
   121  LLSSIFGKQL VVSYFPDKVA LLQRKVEENR NSLFFFLLFL RLFPMTPNWF LNLSAPILNI
   181  PIVQFFFSVL IGLIPYNFIC VQTGSILSTL TSLDALFSWD TVFKLLAIAM VALIPGTLIK
   241  KFSQKHLQLN ETSTANHIHS RKDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM41A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 26 nTPM
duodenum: 25 nTPM
esophagus: 23 nTPM
small intestine: 23 nTPM
liver: 20 nTPM
skin: 19 nTPM

Single-cell type

enterocytes: 244 nCPM
esophageal suprabasal cells: 179 nCPM
esophageal apical cells: 152 nCPM
suprabasal keratinocytes: 106 nCPM
pancreatic acinar cells: 100 nCPM
alveolar cells type 2: 95 nCPM

Immune cell

plasmacytoid DC: 22 nTPM
MAIT T-cell: 21 nTPM
naive CD8 T-cell: 20 nTPM
naive CD4 T-cell: 18 nTPM
memory CD8 T-cell: 18 nTPM
memory B-cell: 18 nTPM

Brain region

thalamus: 17 nTPM
midbrain: 16 nTPM
white matter: 15 nTPM
cerebral cortex: 13 nTPM
cerebellum: 12 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM41A as an antibody target. Whether an autoantibody or antibody against TMEM41A could matter depends on whether native TMEM41A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM41A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM41A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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