Seroatlas · Human Serome Atlas

TMEM39B

Transmembrane protein 39B

Also known as: FLJ10315, TM39B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZU3
Gene: TMEM39B
Ensembl: ENSG00000121775
Chromosome: 1
Canonical length: 492 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q9GZU3|TMEM39B
     1  MGGRRGPNRT SYCRNPLCEP GSSGGSSGSH TSSASVTSVR SRTRSSSGTG LSSPPLATQT
    61  VVPLQHCKIP ELPVQASILF ELQLFFCQLI ALFVHYINIY KTVWWYPPSH PPSHTSLNFH
   121  LIDFNLLMVT TIVLGRRFIG SIVKEASQRG KVSLFRSILL FLTRFTVLTA TGWSLCRSLI
   181  HLFRTYSFLN LLFLCYPFGM YIPFLQLNCD LRKTSLFNHM ASMGPREAVS GLAKSRDYLL
   241  TLRETWKQHT RQLYGPDAMP THACCLSPSL IRSEVEFLKM DFNWRMKEVL VSSMLSAYYV
   301  AFVPVWFVKN THYYDKRWSC ELFLLVSIST SVILMQHLLP ASYCDLLHKA AAHLGCWQKV
   361  DPALCSNVLQ HPWTEECMWP QGVLVKHSKN VYKAVGHYNV AIPSDVSHFR FHFFFSKPLR
   421  ILNILLLLEG AVIVYQLYSL MSSEKWHQTI SLALILFSNY YAFFKLLRDR LVLGKAYSYS
   481  ASPQRDLDHR FS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM39B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

endometrium: 9.8 nTPM
cervix: 8.8 nTPM
blood vessel: 8.4 nTPM
thymus: 7.8 nTPM
fallopian tube: 7.6 nTPM
urinary bladder: 7.6 nTPM

Single-cell type

platelets: 62 nCPM
syncytiotrophoblasts: 56 nCPM
cytotrophoblasts: 44 nCPM
migrating cytotrophoblasts: 38 nCPM
undifferentiated spermatogonia: 35 nCPM
tuft cells: 35 nCPM

Immune cell

plasmacytoid DC: 34 nTPM
myeloid DC: 23 nTPM
classical monocyte: 22 nTPM
intermediate monocyte: 19 nTPM
memory B-cell: 18 nTPM
naive B-cell: 16 nTPM

Brain region

cerebral cortex: 4.9 nTPM
hypothalamus: 3.6 nTPM
medulla oblongata: 3.5 nTPM
pons: 3.4 nTPM
midbrain: 3.3 nTPM
basal ganglia: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.01
gnomAD missense Z: 1.85
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM39B as an antibody target. Whether an autoantibody or antibody against TMEM39B could matter depends on whether native TMEM39B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM39B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM39B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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