Seroatlas · Human Serome Atlas

TMEM38B

Trimeric intracellular cation channel type B

Also known as: bA219P18.1, C9orf87, D4Ertd89e, FLJ10493, TM38B_HUMAN, TRIC-B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVV0
Gene
TMEM38B
Ensembl
ENSG00000095209
Chromosome
9
Canonical length
291 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q9NVV0|TMEM38B
     1  MDSPWDELAL AFSRTSMFPF FDIAHYLVSV MAVKRQPGAA ALAWKNPISS WFTAMLHCFG
    61  GGILSCLLLA EPPLKFLANH TNILLASSIW YITFFCPHDL VSQGYSYLPV QLLASGMKEV
   121  TRTWKIVGGV THANSYYKNG WIVMIAIGWA RGAGGTIITN FERLVKGDWK PEGDEWLKMS
   181  YPAKVTLLGS VIFTFQHTQH LAISKHNLMF LYTIFIVATK ITMMTTQTST MTFAPFEDTL
   241  SWMLFGWQQP FSSCEKKSEA KSPSNGVGSL ASKPVDVASD NVKKKHTKKN E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM38B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 71 nTPM
  • tongue: 58 nTPM
  • heart muscle: 28 nTPM
  • kidney: 27 nTPM
  • testis: 26 nTPM
  • thyroid gland: 26 nTPM

Single-cell type

  • late spermatids: 835 nCPM
  • myonuclei: 770 nCPM
  • early spermatids: 322 nCPM
  • late primary spermatocytes: 240 nCPM
  • thymic myoid cells: 214 nCPM
  • cardiomyocytes: 152 nCPM

Immune cell

  • memory B-cell: 57 nTPM
  • naive B-cell: 57 nTPM
  • eosinophil: 54 nTPM
  • plasmacytoid DC: 52 nTPM
  • naive CD4 T-cell: 39 nTPM
  • intermediate monocyte: 30 nTPM

Brain region

  • white matter: 43 nTPM
  • cerebellum: 37 nTPM
  • pons: 36 nTPM
  • hypothalamus: 35 nTPM
  • choroid plexus: 33 nTPM
  • medulla oblongata: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM38B.

Disease | AllUniProt

Conditions TMEM38B is implicated in, by any mechanism.

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 218 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.02
gnomAD missense Z
-0.05
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM38B as an antibody target. Whether an autoantibody or antibody against TMEM38B could matter depends on whether native TMEM38B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM38B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM38B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM38B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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