Seroatlas · Human Serome Atlas

TMEM37

Voltage-dependent calcium channel gamma-like subunit

Also known as: CCGL_HUMAN, PR, PR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXS4
Gene: TMEM37
Ensembl: ENSG00000171227
Chromosome: 2
Canonical length: 190 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable calcium channel activity and voltage-gated monoatomic ion channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q8WXS4|TMEM37
     1  MTAVGVQAQR PLGQRQPRRS FFESFIRTLI ITCVALAVVL SSVSICDGHW LLAEDRLFGL
    61  WHFCTTTNQT ICFRDLGQAH VPGLAVGMGL VRSVGALAVV AAIFGLEFLM VSQLCEDKHS
   121  QCKWVMGSIL LLVSFVLSSG GLLGFVILLR NQVTLIGFTL MFWCEFTASF LLFLNAISGL
   181  HINSITHPWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 117 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 117 nTPM
liver: 95 nTPM
kidney: 94 nTPM
small intestine: 73 nTPM
duodenum: 50 nTPM
adipose tissue: 50 nTPM

Single-cell type

enterocytes: 545 nCPM
decidual stromal cells: 458 nCPM
hepatocytes: 219 nCPM
kupffer cells: 164 nCPM
syncytiotrophoblasts: 154 nCPM
colonocytes: 127 nCPM

Immune cell

naive CD4 T-cell: 0.9 nTPM
intermediate monocyte: 0.8 nTPM
non-classical monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

thalamus: 7 nTPM
white matter: 5 nTPM
medulla oblongata: 3.6 nTPM
spinal cord: 3.6 nTPM
choroid plexus: 3.5 nTPM
pons: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.73
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

monoatomic ion channel complex

Protein domainsUniProt · Pfam · InterPro

Voltage-dependent calcium channel gamma-like subunit
Voltage-dependent calcium channel gamma-like subunit protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM37 as an antibody target. Whether an autoantibody or antibody against TMEM37 could matter depends on whether native TMEM37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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