Seroatlas · Human Serome Atlas

TMEM35B

Transmembrane protein 35B

Also known as: TM35B_HUMAN, ZMYM6NB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCS4
Gene
TMEM35B
Ensembl
ENSG00000243749
Chromosome
1
Canonical length
154 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q8NCS4|TMEM35B
     1  MALLLSVLRV LLGGFFALVG LAKLSEEISA PVSERMNALF VQFAEVFPLK VFGYQPDPLN
    61  YQIAVGFLEL LAGLLLVMGP PMLQEISNLF LILLMMGAIF TLAALKESLS TCIPAIVCLG
   121  FLLLLNVGQL LAQTKKVVRP TRKKTLSTFK ESWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM35B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 49 nTPM
  • adipose tissue: 46 nTPM
  • lung: 42 nTPM
  • blood vessel: 41 nTPM
  • thyroid gland: 40 nTPM
  • breast: 39 nTPM

Single-cell type

  • microglia: 1.1 nCPM
  • endometrial secretory cells: 1 nCPM
  • adrenal cortex cells: 0.4 nCPM
  • basal prostatic cells: 0.3 nCPM
  • astrocytes: 0.2 nCPM
  • breast lactating cells: 0.2 nCPM

Immune cell

  • T-reg: 197 nTPM
  • memory CD8 T-cell: 176 nTPM
  • memory CD4 T-cell: 174 nTPM
  • MAIT T-cell: 172 nTPM
  • gdT-cell: 160 nTPM
  • total PBMC: 155 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • white matter: 7.3 nTPM
  • medulla oblongata: 6.5 nTPM
  • thalamus: 6.1 nTPM
  • spinal cord: 5.9 nTPM
  • hypothalamus: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0.22
DepMap mean gene effect
-0.1
DepMap dependency class
selective

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM35B as an antibody target. Whether an autoantibody or antibody against TMEM35B could matter depends on whether native TMEM35B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM35B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM35B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM35B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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