Seroatlas · Human Serome Atlas

TMEM278

Transmembrane protein 278

Also known as: TM278_HUMAN, TMEM88B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKF7
Gene: TMEM278
Ensembl: ENSG00000205116
Chromosome: 1
Canonical length: 163 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>A6NKF7|TMEM278
     1  MSEQGRETEE EEGGGGASDT APMLPRGPPD HQASALTCPG WSGPPLLPGR LLAGLLLHLL
    61  LPAAAFLLVL LPAAAVVYLG FLCHSRVHPA PGPRCRALFS DRGSAALIVF GLLSLPPLLV
   121  LASAVRARLA RRLRPLLPPP AGTPGPRRPP GRPDEDEQLC AWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM278 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 192 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 192 nTPM
midbrain: 108 nTPM
hippocampal formation: 83 nTPM
basal ganglia: 59 nTPM
amygdala: 47 nTPM
hypothalamus: 45 nTPM

Single-cell type

sertoli cells: 2.8 nCPM
oligodendrocytes: 2.7 nCPM
thymocytes: 1.7 nCPM
schwann cells: 1.6 nCPM
myosatellite cells: 1.3 nCPM
fibro-adipogenic progenitors: 1.1 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.6 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

white matter: 322 nTPM
basal ganglia: 217 nTPM
medulla oblongata: 212 nTPM
thalamus: 189 nTPM
midbrain: 188 nTPM
cerebral cortex: 179 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0.43
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of canonical Wnt signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 88

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM278 as an antibody target. Whether an autoantibody or antibody against TMEM278 could matter depends on whether native TMEM278 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM278 is annotated at the cell surface, where native TMEM278 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM278 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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