Seroatlas · Human Serome Atlas

TMEM276

Transmembrane protein 276

Also known as: TM276_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DTL5
Gene
TMEM276
Canonical length
192 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for TMEM276 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>P0DTL5|TMEM276
     1  MAPKPGAEWS TALSHLVLGV VSLHAAVSTA EASRGAAAGF LLQVLAATTT LAPGLSTHED
    61  CLAGAWVATV IGLPLLAFDF HWVNGDRSSA NLLLGGGMVL AVAGGHLGPE GRSVAGQAML
   121  LVVAVTILIV AVFTANTYGM WGGAMLGVAG LLSRLEEDRL LLLPKEDVCR WALAVGSWAY
   181  CRALHTQRLQ WE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM276 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 34 nTPM
  • salivary gland: 30 nTPM
  • pancreas: 27 nTPM
  • heart muscle: 21 nTPM
  • seminal vesicle: 20 nTPM
  • parathyroid gland: 19 nTPM

Single-cell type

  • megakaryocytes: 6.2 nCPM
  • cholangiocytes: 3.9 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • epididymal principal cells: 2.8 nCPM
  • mucous neck cells: 2.8 nCPM
  • lacrimal acinar cells: 2.7 nCPM

Immune cell

  • plasmacytoid DC: 26 nTPM
  • naive CD4 T-cell: 21 nTPM
  • MAIT T-cell: 15 nTPM
  • naive B-cell: 13 nTPM
  • memory B-cell: 12 nTPM
  • naive CD8 T-cell: 12 nTPM

Brain region

  • medulla oblongata: 30 nTPM
  • white matter: 30 nTPM
  • spinal cord: 27 nTPM
  • cerebellum: 27 nTPM
  • hippocampal formation: 26 nTPM
  • cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect
-0.26
DepMap dependency class
selective

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM276 as an antibody target. Whether an autoantibody or antibody against TMEM276 could matter depends on whether native TMEM276 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM276 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM276 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM276. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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