Seroatlas · Human Serome Atlas

TMEM275

Transmembrane protein 275

Also known as: TM275_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0U1RQS6
Gene
TMEM275
Ensembl
ENSG00000282881
Chromosome
1
Canonical length
177 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>A0A0U1RQS6|TMEM275
     1  MPPAEKSEGP PVPAPAERAR GRVPGLPSPA LCCACGLCAL LAGVNVTLAG AFASFLPEHN
    61  ALLVVGLALL VLALGFFAAC CVCSRRGLAP RGRSAAAAGP GQGGGRAGPV ALEMESSEPT
   121  AQDTTAVQLS PAVSAASSGC SSPGPSPLAL EAPAPAAVCA LRSEGVQLNP PRARAAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM275 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 1.3 nTPM
  • amygdala: 1.2 nTPM
  • testis: 0.9 nTPM
  • cerebral cortex: 0.7 nTPM
  • hippocampal formation: 0.5 nTPM
  • basal ganglia: 0.3 nTPM

Single-cell type

  • late spermatids: 175 nCPM
  • early spermatids: 125 nCPM
  • late primary spermatocytes: 10 nCPM
  • other brain neurons: 6.7 nCPM
  • brain excitatory neurons: 5.1 nCPM
  • brain inhibitory neurons: 3.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 4.5 nTPM
  • cerebral cortex: 4.1 nTPM
  • hypothalamus: 3.6 nTPM
  • amygdala: 3.4 nTPM
  • basal ganglia: 3.3 nTPM
  • spinal cord: 2.7 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM275 as an antibody target. Whether an autoantibody or antibody against TMEM275 could matter depends on whether native TMEM275 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM275 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM275 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM275. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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