Seroatlas · Human Serome Atlas

TMEM273

Transmembrane protein 273

Also known as: C10orf128, Em:AC084727.5, TM273_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T292
Gene
TMEM273
Ensembl
ENSG00000204161
Chromosome
10
Canonical length
105 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>Q5T292|TMEM273
     1  MNLGVSMLRI LFLLDVGGAQ VLATGKTPGA EIDFKYALIG TAVGVAISAG FLALKICMIR
    61  RHLFDDDSSD LKSTPGGLSD TIPLKKRAPR RNHNFSKRDA QVIEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM273 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 46 nTPM
  • adipose tissue: 30 nTPM
  • spleen: 28 nTPM
  • heart muscle: 27 nTPM
  • breast: 26 nTPM
  • lung: 26 nTPM

Single-cell type

  • hofbauer cells: 194 nCPM
  • mast cells: 92 nCPM
  • neutrophils: 87 nCPM
  • vascular endothelial cells: 62 nCPM
  • microglia: 58 nCPM
  • cdc: 51 nCPM

Immune cell

  • eosinophil: 270 nTPM
  • MAIT T-cell: 37 nTPM
  • memory B-cell: 36 nTPM
  • basophil: 25 nTPM
  • gdT-cell: 23 nTPM
  • memory CD8 T-cell: 22 nTPM

Brain region

  • white matter: 39 nTPM
  • medulla oblongata: 29 nTPM
  • cerebellum: 24 nTPM
  • midbrain: 24 nTPM
  • pons: 24 nTPM
  • basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0.01
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4514
  • Domain of unknown function (DUF4514)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM273 as an antibody target. Whether an autoantibody or antibody against TMEM273 could matter depends on whether native TMEM273 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM273 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM273 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM273. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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