Seroatlas · Human Serome Atlas

TMEM272

Transmembrane protein 272

Also known as: FLJ37307, LINC00282, NCRNA00282, TM272_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTI8
Gene
TMEM272
Ensembl
ENSG00000281106
Chromosome
13
Canonical length
187 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>A0A1B0GTI8|TMEM272
     1  MPGGLEKTCH QCISKIASNA CFVVVLCAFL ALPLSMTFIG MKFLEDCPIQ PLIPLYLLVG
    61  GIVGTLKVSL LLYDSTRMRR LLSKAVVIDD DDDDEYPWRQ NAHRYYIHLL LSLFLFLWFI
   121  LGNYWVFSVY LPDFLPPFQQ PQDYCDKTLY LFAVGVLALS HTVLVLLLLC SGCVYLCSRW
   181  RLAADED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM272 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 14 nTPM
  • retina: 2.7 nTPM
  • amygdala: 1.9 nTPM
  • heart muscle: 1.3 nTPM
  • hippocampal formation: 1.2 nTPM
  • hypothalamus: 1.2 nTPM

Single-cell type

  • late spermatids: 11 nCPM
  • melanocytes: 6.3 nCPM
  • early spermatids: 3 nCPM
  • neutrophils: 1.7 nCPM
  • brain inhibitory neurons: 0.2 nCPM
  • leydig cells: 0.2 nCPM

Immune cell

  • neutrophil: 40 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • basal ganglia: 35 nTPM
  • amygdala: 10 nTPM
  • hippocampal formation: 5.7 nTPM
  • cerebral cortex: 5.6 nTPM
  • thalamus: 5.4 nTPM
  • hypothalamus: 5 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 272

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM272 as an antibody target. Whether an autoantibody or antibody against TMEM272 could matter depends on whether native TMEM272 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM272 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM272 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM272. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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