Seroatlas · Human Serome Atlas

TMEM271

Transmembrane protein 271

Also known as: TM271_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A286YF58
Gene
TMEM271
Ensembl
ENSG00000273238
Chromosome
4
Canonical length
385 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>A0A286YF58|TMEM271
     1  MKWSVRGACA ALSSCLLLAC ALSAAAVGLK CFSLGSELRG EPFRLGAAAG AFYSGLLLAA
    61  GLSLLGAALL CCGPRDAPLA GSEPGPGLGV PAAPAGAPEA TPGESGAAAG APGPVSSQNL
   121  LLLGVLVFML GVLSAFAGAV IDGDTVSLVE RKYSHYCLPP RAPGSSPGSA PGSTPGSAPG
   181  SAPGSAPGSA PGAPRARSTL DSATSAKCRQ LKDYQRGLVL STVFNSLECL LGLLSLLLVK
   241  NYKSSQARRG RRGRRRGGRA LARPRGGSGL RAQPPASRAR RGRRGRRGRR LQQRPSEASI
   301  LSPEESDLAA PGDCAGFAAH HAVSYINVGV LHALDEAGAE VRCGGHPSVE LPGYAPSDPD
   361  LNASYPYCCR PPCETPRPWE THRAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM271 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 20 nTPM
  • cerebral cortex: 19 nTPM
  • basal ganglia: 17 nTPM
  • amygdala: 16 nTPM
  • hypothalamus: 11 nTPM
  • pituitary gland: 6 nTPM

Single-cell type

  • other brain neurons: 16 nCPM
  • brain inhibitory neurons: 12 nCPM
  • brain excitatory neurons: 11 nCPM
  • adrenal medulla cells: 11 nCPM
  • retinal amacrine cells: 11 nCPM
  • somatotrophs: 7.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 59 nTPM
  • hippocampal formation: 49 nTPM
  • amygdala: 39 nTPM
  • basal ganglia: 36 nTPM
  • hypothalamus: 34 nTPM
  • white matter: 27 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM271 as an antibody target. Whether an autoantibody or antibody against TMEM271 could matter depends on whether native TMEM271 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM271 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM271 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM271. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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