Seroatlas · Human Serome Atlas

TMEM270

Transmembrane protein 270

Also known as: MGC26719, TM270_HUMAN, WBSCR28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UE05
Gene: TMEM270
Ensembl: ENSG00000175877
Chromosome: 7
Canonical length: 265 aa
Protein class: Human disease related genes, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q6UE05|TMEM270
     1  MEALPPVRSS LLGILLQVTR LSVLLVQNRD HLYNFLLLKI NLFNHWVSGL AQEARGSCNW
    61  QAHLPLGAAA CPLGQALWAG LALIQVPVWL VLQGPRLMWA GMWGSTKGLG LALLSAWEQL
   121  GLSVAIWTDL FLSCLHGLML VALLLVVVTW RVCQKSHCFR LGRQLSKALQ VNCVVRKLLV
   181  QLRRLYWWVE TMTALTSWHL AYLITWTTCL ASHLLQAAFE HTTQLAEAQE VEPQEVSGSS
   241  LLPSLSASSD SESGTVLPEQ ETPRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM270 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

testis: 75 nTPM
duodenum: 0.3 nTPM
pituitary gland: 0.3 nTPM
hippocampal formation: 0.2 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM

Single-cell type

early spermatids: 1,091 nCPM
late spermatids: 387 nCPM
late primary spermatocytes: 311 nCPM
respiratory ciliated cells: 6.1 nCPM
sertoli cells: 4.8 nCPM
urothelial cells: 4.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Williams-Beuren syndrome chromosomal region 28 protein homologue
Williams-Beuren syndrome chromosomal region 28 protein homologue

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM270 as an antibody target. Whether an autoantibody or antibody against TMEM270 could matter depends on whether native TMEM270 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM270 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM270 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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