Seroatlas · Human Serome Atlas

TMEM269

Transmembrane protein 269

Also known as: TM269_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVZ9
Gene
TMEM269
Ensembl
ENSG00000274386
Chromosome
1
Canonical length
203 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>A0A1B0GVZ9|TMEM269
     1  MVLGLFSIIF SFSRKCHYAS RMLLVSFLLD MAVRAMTSHI NICSKLGAEL NDFAVFTTFG
    61  LASALLLGVD GLLSGILAII YVSAASFHLC FYSPGVPSTY KGLPCPYASC ILASTSLLTK
   121  GNRFILCCMA SLMILFMMDQ SYYPYDKILE SENWKKLVYI GGVIMLFFSP LSLSAFYCLM
   181  WSLSYIFFPD ALWGKAACLS PQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM269 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
0.9 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.9 nTPM
  • skeletal muscle: 0.5 nTPM
  • cerebellum: 0.4 nTPM
  • testis: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • bone marrow: 0.3 nTPM

Single-cell type

  • late spermatids: 122 nCPM
  • early spermatids: 26 nCPM
  • cardiomyocytes: 15 nCPM
  • epicardial cells: 14 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • medullary thymic epithelial cells: 7.2 nCPM

Immune cell

  • neutrophil: 0.4 nTPM
  • basophil: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebellum: 2.8 nTPM
  • white matter: 2.3 nTPM
  • cerebral cortex: 1.9 nTPM
  • basal ganglia: 1.8 nTPM
  • hippocampal formation: 1.8 nTPM
  • pons: 1.8 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM269 as an antibody target. Whether an autoantibody or antibody against TMEM269 could matter depends on whether native TMEM269 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM269 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM269 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM269. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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