Seroatlas · Human Serome Atlas

TMEM267

Transmembrane protein 267

Also known as: C5orf28, FLJ21657, TM267_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q0VDI3
Gene
TMEM267
Ensembl
ENSG00000151881
Chromosome
5
Canonical length
215 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q0VDI3|TMEM267
     1  MASETEKTHA LLQTCSTESL ISSLGLGAFC LVADRLLQFS TIQQNDWLRA LSDNAVHCVI
    61  GMWSWAVVTG IKKKTDFGEI ILAGFLASVI DVDHFFLAGS MSLKAALTLP RRPFLHCSTV
   121  IPVVVLTLKF TMHLFKLKDS WCFLPWMLFI SWTSHHIRDG IRHGLWICPF GKTSPLPFWL
   181  YVIITSSLPH ICSFVMYLTG TRQMMSSKHG VRIDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM267 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 36 nTPM
  • breast: 14 nTPM
  • epididymis: 11 nTPM
  • cervix: 10 nTPM
  • parathyroid gland: 10 nTPM
  • skin: 9.8 nTPM

Single-cell type

  • sertoli cells: 118 nCPM
  • hepatic stellate cells: 65 nCPM
  • cytotrophoblasts: 61 nCPM
  • breast lactating cells: 60 nCPM
  • mucous neck cells: 60 nCPM
  • b-cells: 58 nCPM

Immune cell

  • MAIT T-cell: 22 nTPM
  • naive CD4 T-cell: 20 nTPM
  • memory CD4 T-cell: 20 nTPM
  • NK-cell: 19 nTPM
  • T-reg: 18 nTPM
  • basophil: 17 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • midbrain: 12 nTPM
  • pons: 12 nTPM
  • hypothalamus: 11 nTPM
  • medulla oblongata: 11 nTPM
  • white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 267

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM267 as an antibody target. Whether an autoantibody or antibody against TMEM267 could matter depends on whether native TMEM267 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM267 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM267 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM267. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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