Seroatlas · Human Serome Atlas

TMEM266

Transmembrane protein 266

Also known as: C15orf27, FLJ38190, TM266_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2M3C6
Gene
TMEM266
Ensembl
ENSG00000169758
Chromosome
15
Canonical length
523 aa
Protein class
Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables protein homodimerization activity. Predicted to be involved in transmembrane transport. Located in cytosol; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q2M3C6|TMEM266
     1  MTNPQPAIEG GISEVEIISQ QVDEETKSIA PVQLVNFAYR DLPLAAVDLS TAGSQLLSNL
    61  DEDYQREGSN WLKPCCGKRA AVWQVFLLSA SLNSFLVACV ILVVILLTLE LLIDIKLLQF
   121  SSAFQFAGVI HWISLVILSV FFSETVLRIV VLGIWDYIEN KIEVFDGAVI ILSLAPMVAS
   181  TVANGPRSPW DAISLIIMLR IWRVKRVIDA YVLPVKLEME MVIQQYEKAK VIQDEQLERL
   241  TQICQEQGFE IRQLRAHLAQ QDLDLAAERE AALQAPHVLS QPRSRFKVLE AGTWDEETAA
   301  ESVVEELQPS QEATMKDDMN SYISQYYNGP SSDSGVPEPA VCMVTTAAID IHQPNISSDL
   361  FSLDMPLKLG GNGTSATSES ASRSSVTRAQ SDSSQTLGSS MDCSTAREEP SSEPGPSPPP
   421  LPSQQQVEEA TVQDLLSSLS EDPCPSQKAL DPAPLARPSP AGSAQTSPEL EHRVSLFNQK
   481  NQEGFTVFQI RPVIHFQPTV PMLEDKFRSL ESKEQKLHRV PEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM266 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 17 nTPM
  • skeletal muscle: 5.5 nTPM
  • cerebral cortex: 2.3 nTPM
  • tongue: 2.1 nTPM
  • pituitary gland: 1.6 nTPM
  • pancreas: 1.3 nTPM

Single-cell type

  • podocytes: 326 nCPM
  • cardiomyocytes: 147 nCPM
  • brain excitatory neurons: 125 nCPM
  • gonadotrophs: 104 nCPM
  • oocytes: 101 nCPM
  • retinal amacrine cells: 73 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 18 nTPM
  • cerebral cortex: 3.7 nTPM
  • hypothalamus: 2.9 nTPM
  • basal ganglia: 2 nTPM
  • midbrain: 1.8 nTPM
  • amygdala: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM266 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM266 as an antibody target. Whether an autoantibody or antibody against TMEM266 could matter depends on whether native TMEM266 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM266 is annotated at the cell surface, where native TMEM266 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM266 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM266. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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