Seroatlas · Human Serome Atlas

TMEM263

Transmembrane protein 263

Also known as: C12orf23, MGC17943, TM263_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUH6
Gene
TMEM263
Ensembl
ENSG00000151135
Chromosome
12
Canonical length
116 aa
Protein class
Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q8WUH6|TMEM263
     1  MNQTDKNQQE IPSYLNDEPP EGSMKDHPQQ QPGMLSRVTG GIFSVTKGAV GATIGGVAWI
    61  GGKSLEVTKT AVTTVPSMGI GLVKGGVSAV AGGVTAVGSA VVNKVPLTGK KKDKSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM263 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • liver: 42 nTPM
  • placenta: 41 nTPM
  • cervix: 39 nTPM
  • pituitary gland: 36 nTPM
  • epididymis: 32 nTPM
  • thyroid gland: 32 nTPM

Single-cell type

  • extravillous trophoblasts: 211 nCPM
  • breast lactating cells: 163 nCPM
  • epicardial cells: 150 nCPM
  • plasma cells: 149 nCPM
  • somatotrophs: 140 nCPM
  • epididymal principal cells: 139 nCPM

Immune cell

  • naive CD4 T-cell: 27 nTPM
  • naive CD8 T-cell: 25 nTPM
  • NK-cell: 20 nTPM
  • MAIT T-cell: 18 nTPM
  • T-reg: 17 nTPM
  • naive B-cell: 17 nTPM

Brain region

  • hypothalamus: 49 nTPM
  • choroid plexus: 49 nTPM
  • midbrain: 39 nTPM
  • pons: 38 nTPM
  • basal ganglia: 35 nTPM
  • cerebral cortex: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0.01
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein C12orf23, UPF0444
  • Transmembrane protein C12orf23, UPF0444

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM263 as an antibody target. Whether an autoantibody or antibody against TMEM263 could matter depends on whether native TMEM263 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM263 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM263 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM263. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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