Seroatlas · Human Serome Atlas

TMEM262

Cation channel sperm-associated auxiliary subunit TMEM262

Also known as: TM262_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E9PQX1
Gene
TMEM262
Ensembl
ENSG00000187066
Chromosome
11
Canonical length
116 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in motile cilium and plasma membrane. Predicted to be part of CatSper complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>E9PQX1|TMEM262
     1  MWLQDRIATF FFPKGMMLTT AALMLFFLHL GIFIRDVHNF CITYHYDHMS FHYTVVLMFS
    61  QVISICWAAM GSLYAEMTEN KYVCFSALTI LMLNGAMFFN RLSLEFLAIE YREEHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM262 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • testis: 21 nTPM
  • cervix: 0.1 nTPM
  • skin: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • early spermatids: 185 nCPM
  • late primary spermatocytes: 125 nCPM
  • cardiomyocytes: 28 nCPM
  • epicardial cells: 23 nCPM
  • late spermatids: 12 nCPM
  • adipocytes: 6.2 nCPM

Immune cell

  • memory B-cell: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 1.4 nTPM
  • white matter: 1.4 nTPM
  • thalamus: 1.1 nTPM
  • cerebellum: 0.9 nTPM
  • medulla oblongata: 0.9 nTPM
  • cerebral cortex: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
0
DepMap dependency class
selective

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cation channel sperm-associated auxiliary subunit TMEM262

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM262 as an antibody target. Whether an autoantibody or antibody against TMEM262 could matter depends on whether native TMEM262 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM262 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM262 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM262. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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