Seroatlas · Human Serome Atlas

TMEM260

Protein O-mannosyl-transferase TMEM260

Also known as: C14orf101, FLJ20392, TM260_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX78
Gene: TMEM260
Ensembl: ENSG00000070269
Chromosome: 14
Canonical length: 707 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein maturation. Is active in endoplasmic reticulum membrane. Implicated in T-cell non-Hodgkin lymphoma; non-Hodgkin lymphoma; and stomach cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

707 residues, UniProt reviewed canonical sequence.

>Q9NX78|TMEM260
     1  MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG GDSGELITAA
    61  HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL FGAVAASLLF FTVFRLSGSS
   121  AGGILAAGVF SFSRLTWQWS IAAEVFSLNN LFVGLLMALT VHFEEAATAK ERSKVAKIGA
   181  FCCGLSLCNQ HTIILYVLCI IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS
   241  YLNHARWTWG DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI
   301  QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM GVVERFWMQS
   361  NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV VYQIYSNYSV CDQRTNYVID
   421  KFAKNLLTSM PHDAIILLRG DLPGNSLRYM HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH
   481  LPGVNFPGNR WNPVEGILPS GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP
   541  WGSCDKLVPL EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI
   601  FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM LRLQARDADP
   661  EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS LRNRKNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM260 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

cervix: 37 nTPM
choroid plexus: 11 nTPM
thyroid gland: 7.9 nTPM
epididymis: 7.3 nTPM
fallopian tube: 7 nTPM
ovary: 7 nTPM

Single-cell type

choroid plexus epithelial cells: 849 nCPM
neutrophils: 213 nCPM
early spermatids: 204 nCPM
thyrotrophs: 171 nCPM
neutrophil progenitors: 159 nCPM
lactotrophs: 140 nCPM

Immune cell

NK-cell: 2.5 nTPM
plasmacytoid DC: 1.9 nTPM
gdT-cell: 1.3 nTPM
T-reg: 1.3 nTPM
eosinophil: 1.2 nTPM
naive CD4 T-cell: 1.2 nTPM

Brain region

choroid plexus: 28 nTPM
white matter: 16 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 11 nTPM
cerebellum: 11 nTPM
medulla oblongata: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM260.

Disease | AllUniProt

Conditions TMEM260 is implicated in, by any mechanism.

Structural heart defects and renal anomalies syndrome (SHDRA) MIM:617478

Disease | GeneticClinVar

33 pathogenic / likely-pathogenic of 220 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Structural heart defects and renal anomalies syndrome
Type I truncus arteriosus
TMEM260-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.74
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Protein O-mannosyl-transferase TMEM260, N-terminal domain
Glycosyltransferase 117 domain-containing protein
Protein O-mannosyl-transferase TMEM260-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM260 as an antibody target. Whether an autoantibody or antibody against TMEM260 could matter depends on whether native TMEM260 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM260 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM260 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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