Seroatlas · Human Serome Atlas

TMEM26

Transmembrane protein 26

Also known as: Em:AC068892.1, MGC35010, TMM26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUK4
Gene: TMEM26
Ensembl: ENSG00000196932
Chromosome: 10
Canonical length: 368 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q6ZUK4|TMEM26
     1  MEGLVFLNAL ATRLLFLLHS LVGVWRVTEV KKEPRYWLLA LLNLLLFLET ALTLKFKRGR
    61  GYKWFSPAIF LYLISIVPSL WLLELHHETQ YCSIQAEGTS QNTSRKEDFN QTLTSNEQTS
   121  RADDLIETAK VFVNNLSTVC EKVWTLGLHQ TFLLMLIIGR WLLPIGGGIT RDQLSQLLLM
   181  FVGTAADILE FTSETLEEQN VRNSPALVYA ILVIWTWSML QFPLDLAVQN VVCPVSVTER
   241  GFPSLFFCQY SADLWNIGIS VFIQDGPFLV VRLILMTYFK VINQMLVFFA AKNFLVVVLQ
   301  LYRLVVLALA VRASLRSQSE GLKGEHGCRA QTSESGPSQR DWQNESKEGL AIPLRGSPVT
   361  SDDSHHTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

spleen: 8.3 nTPM
breast: 4.9 nTPM
endometrium: 3.7 nTPM
testis: 3.4 nTPM
prostate: 2.4 nTPM
liver: 2.3 nTPM

Single-cell type

kupffer cells: 166 nCPM
sertoli cells: 63 nCPM
breast hormone-responsive cells: 30 nCPM
macrophages: 22 nCPM
oligodendrocytes: 14 nCPM
prostatic glandular cells: 14 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 3.1 nTPM
amygdala: 2.7 nTPM
basal ganglia: 2.7 nTPM
cerebral cortex: 2.4 nTPM
midbrain: 2 nTPM
hypothalamus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -0.6
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 26
Transmembrane protein 26

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM26 as an antibody target. Whether an autoantibody or antibody against TMEM26 could matter depends on whether native TMEM26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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