Seroatlas · Human Serome Atlas

TMEM259

Membralin

Also known as: ASBABP1, C19orf6, MBRL, MBRL_HUMAN, MGC4022

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4ZIN3
Gene: TMEM259
Ensembl: ENSG00000182087
Chromosome: 19
Canonical length: 620 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nuclear speckles,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be involved in positive regulation of ERAD pathway and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>Q4ZIN3|TMEM259
     1  MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF KMAVTYSRLF
    61  PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH VRDKWPREGI LRVEVRHNSS
   121  RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM EDEEEEELTM EMFGNSSIKF ELDIEPKVFK
   181  PPSSTEALND SQEFPFPETP TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD
   241  PTRDQCFGDR FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA
   301  RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA APLLTVILAL
   361  VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS KRHWLRFFYL YHFAFYAYHY
   421  RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE LPAILQQVRI QEMLLQAPPL GPGTPTALPD
   481  DMNNNSGAPA TAPDSAGQPP ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW
   541  MAETAAIITD ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA
   601  VGGPSPASMA PTEAPSEVGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM259 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 186 nTPM

Expression across tissuesHPA

Tissue

spleen: 186 nTPM
liver: 161 nTPM
pituitary gland: 149 nTPM
cerebellum: 140 nTPM
small intestine: 130 nTPM
thyroid gland: 129 nTPM

Single-cell type

breast lactating cells: 99 nCPM
podocytes: 99 nCPM
astrocytes: 94 nCPM
syncytiotrophoblasts: 90 nCPM
bergmann glia: 89 nCPM
esophageal apical cells: 87 nCPM

Immune cell

plasmacytoid DC: 2.9 nTPM
myeloid DC: 2.5 nTPM
non-classical monocyte: 2.3 nTPM
gdT-cell: 2.2 nTPM
memory CD8 T-cell: 2.2 nTPM
classical monocyte: 1.7 nTPM

Brain region

white matter: 133 nTPM
medulla oblongata: 130 nTPM
cerebral cortex: 128 nTPM
choroid plexus: 128 nTPM
midbrain: 117 nTPM
thalamus: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.99
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Membralin
Tumour-associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM259 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ERLIN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM259 as an antibody target. Whether an autoantibody or antibody against TMEM259 could matter depends on whether native TMEM259 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM259 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM259 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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