Seroatlas · Human Serome Atlas

TMEM258

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

Also known as: C11orf10, Kud, Kuduk, TM258_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61165
Gene: TMEM258
Ensembl: ENSG00000134825
Chromosome: 11
Canonical length: 79 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable oligosaccharyltransferase complex binding activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum and membrane. Part of oligosaccharyltransferase complex A and oligosaccharyltransferase complex B. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>P61165|TMEM258
     1  MELEAMSRYT SPVNPAVFPH LTVVLLAIGM FFTAWFFVYE VTSTKYTRDI YKELLISLVA
    61  SLFMGFGVLF LLLWVGIYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM258 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 330 nTPM

Expression across tissuesHPA

Tissue

epididymis: 330 nTPM
pancreas: 283 nTPM
choroid plexus: 174 nTPM
salivary gland: 173 nTPM
heart muscle: 160 nTPM
adrenal gland: 149 nTPM

Single-cell type

epididymal principal cells: 1,391 nCPM
epicardial cells: 1,101 nCPM
plasma cells: 866 nCPM
extravillous trophoblasts: 865 nCPM
parietal cells: 845 nCPM
gastric chief cells: 743 nCPM

Immune cell

basophil: 511 nTPM
plasmacytoid DC: 498 nTPM
eosinophil: 288 nTPM
total PBMC: 245 nTPM
T-reg: 237 nTPM
memory B-cell: 234 nTPM

Brain region

white matter: 74 nTPM
spinal cord: 57 nTPM
cerebellum: 57 nTPM
medulla oblongata: 56 nTPM
hypothalamus: 52 nTPM
basal ganglia: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.85
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

oligosaccharyltransferase complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Oligosaccharyltransferase complex subunit
Oligosaccharyltransferase subunit 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM258 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SYNE1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM258 as an antibody target. Whether an autoantibody or antibody against TMEM258 could matter depends on whether native TMEM258 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM258 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM258 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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