Seroatlas · Human Serome Atlas

TMEM255B

Transmembrane protein 255B

Also known as: FAM70B, MGC20579, T255B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV15
Gene: TMEM255B
Ensembl: ENSG00000184497
Chromosome: 13
Canonical length: 326 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q8WV15|TMEM255B
     1  MQPPVPGPLG LLDPAEGLSR RKKTSLWFVG SLLLVSVLIV TVGLAATTRT ENVTVGGYYP
    61  GIILGFGSFL GIIGINLVEN RRQMLVAAIV FISFGVVAAF CCAIVDGVFA AQHIEPRPLT
   121  TGRCQFYSSG VGYLYDVYQT EVTCHSLDGK CQLKVRSNTC YCCDLYACGS AEPSPAYYEF
   181  IGVSGCQDVL HLYRLLWASA VLNVLGLFLG IITAAVLGAF KDMVPLSQLA YGPAVPPQTL
   241  YNPAQQILAY AGFRLTPEPV PTCSSYPLPL QPCSRFPVAP SSALASSEDL QPPSPSSSGS
   301  GLPGQAPPCY APTYFPPGEK PPPYAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM255B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 13 nTPM
lung: 12 nTPM
thyroid gland: 11 nTPM
breast: 10 nTPM
kidney: 9.1 nTPM
blood vessel: 7.7 nTPM

Single-cell type

lymphatic endothelial cells: 110 nCPM
vascular endothelial cells: 101 nCPM
mast cells: 45 nCPM
microglia: 23 nCPM
macrophages: 22 nCPM
hofbauer cells: 21 nCPM

Immune cell

basophil: 31 nTPM
intermediate monocyte: 5.5 nTPM
classical monocyte: 5.4 nTPM
non-classical monocyte: 4 nTPM
naive B-cell: 2.8 nTPM
neutrophil: 2.7 nTPM

Brain region

hypothalamus: 8.7 nTPM
medulla oblongata: 5.5 nTPM
choroid plexus: 5.3 nTPM
thalamus: 4.9 nTPM
pons: 4.4 nTPM
cerebral cortex: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM255B as an antibody target. Whether an autoantibody or antibody against TMEM255B could matter depends on whether native TMEM255B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM255B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM255B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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