Seroatlas · Human Serome Atlas

TMEM252

Transmembrane protein 252

Also known as: C9orf71, MGC34760, TM252_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6L7
Gene
TMEM252
Ensembl
ENSG00000181778
Chromosome
9
Canonical length
170 aa
Protein class
Predicted membrane proteins
Subcellular location
Nuclear speckles,Plasma membrane,Primary cilium,Basal body

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q8N6L7|TMEM252
     1  MQNRTGLILC ALALLMGFLM VCLGAFFISW GSIFDCQGSL IAAYLLLPLG FVILLSGIFW
    61  SNYRQVTESK GVLRHMLRQH LAHGALPVAT VDRPDFYPPA YEESLEVEKQ SCPAEREASG
   121  IPPPLYTETG LEFQDGNDSH PEAPPSYRES IAGLVVTAIS EDAQRRGQEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM252 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 33 nTPM
  • small intestine: 21 nTPM
  • colon: 7.5 nTPM
  • urinary bladder: 5.8 nTPM
  • esophagus: 5.6 nTPM
  • endometrium: 4.8 nTPM

Single-cell type

  • enterocytes: 57 nCPM
  • proximal tubule cells: 12 nCPM
  • cardiomyocytes: 7.5 nCPM
  • endometrial glandular cells: 5.9 nCPM
  • paneth cells: 3.9 nCPM
  • enteric transient amplifying cells: 3.5 nCPM

Immune cell

  • neutrophil: 4.1 nTPM
  • eosinophil: 0.5 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 2.6 nTPM
  • hypothalamus: 0.9 nTPM
  • pons: 0.4 nTPM
  • amygdala: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM
  • midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0.2
gnomAD missense Z
-0.23
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 252
  • Transmembrane protein 252 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM252 as an antibody target. Whether an autoantibody or antibody against TMEM252 could matter depends on whether native TMEM252 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM252 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM252 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM252. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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