Seroatlas · Human Serome Atlas

TMEM248

Transmembrane protein 248

Also known as: C7orf42, FLJ10099, FLJ13090, TM248_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWD8
Gene: TMEM248
Ensembl: ENSG00000106609
Chromosome: 7
Canonical length: 314 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q9NWD8|TMEM248
     1  MFSINPLENL KVYISSRPPL VVFMISVSAM AIAFLTLGYF FKIKEIKSPE MAEDWNTFLL
    61  RFNDLDLCVS ENETLKHLTN DTTTPESTMT SGQARASTQS PQALEDSGPV NISVSITLTL
   121  DPLKPFGGYS RNVTHLYSTI LGHQIGLSGR EAHEEINITF TLPTAWSSDD CALHGHCEQV
   181  VFTACMTLTA SPGVFPVTVQ PPHCVPDTYS NATLWYKIFT TARDANTKYA QDYNPFWCYK
   241  GAIGKVYHAL NPKLTVIVPD DDRSLINLHL MHTSYFLFVM VITMFCYAVI KGRPSKLRQS
   301  NPEFCPEKVA LAEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM248 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 64 nTPM
blood vessel: 48 nTPM
parathyroid gland: 47 nTPM
liver: 46 nTPM
ovary: 44 nTPM
cervix: 44 nTPM

Single-cell type

late spermatids: 271 nCPM
esophageal apical cells: 228 nCPM
late primary spermatocytes: 150 nCPM
gastric progenitor cells: 146 nCPM
foveolar cells: 131 nCPM
hepatocytes: 131 nCPM

Immune cell

memory B-cell: 8.3 nTPM
plasmacytoid DC: 8.3 nTPM
naive B-cell: 8.2 nTPM
eosinophil: 7.7 nTPM
NK-cell: 7.3 nTPM
MAIT T-cell: 7.2 nTPM

Brain region

choroid plexus: 120 nTPM
hypothalamus: 82 nTPM
hippocampal formation: 66 nTPM
midbrain: 65 nTPM
pons: 65 nTPM
basal ganglia: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.74
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM248 as an antibody target. Whether an autoantibody or antibody against TMEM248 could matter depends on whether native TMEM248 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM248 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM248 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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