Seroatlas · Human Serome Atlas

TMEM247

Transmembrane protein 247

Also known as: TM247_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NEH6
Gene
TMEM247
Ensembl
ENSG00000284701
Chromosome
2
Canonical length
219 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>A6NEH6|TMEM247
     1  MAAEDREMME ARGAGESCPT FPKMVPGDSK SEGKPRAYLE AESQKPDSSY DYLEEMEACE
    61  DGGCQGPLKS LSPKSCRATK GQAGDGPKPA ELPPTPGTER NPEMELEKVR MEFELTRLKY
   121  LHEKNQRQRQ HEVVMEQLQR ERQHEVVMEQ LQQEAAPRLF SGGLQNFLLP QNQFAMFLYC
   181  FIFIHIIYVT KEMVFFLFAK HYLFCIAAIL LCLIKTFWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM247 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • testis: 46 nTPM
  • placenta: 1.4 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 448 nCPM
  • early spermatids: 419 nCPM
  • late primary spermatocytes: 220 nCPM
  • syncytiotrophoblasts: 29 nCPM
  • migrating cytotrophoblasts: 8.5 nCPM
  • cytotrophoblasts: 8.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.2 nTPM
  • cerebral cortex: 1 nTPM
  • amygdala: 0.9 nTPM
  • hypothalamus: 0.9 nTPM
  • basal ganglia: 0.8 nTPM
  • hippocampal formation: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.66
gnomAD pLI
0
gnomAD missense Z
-0.22
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 247
  • Transmembrane protein 247

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM247 as an antibody target. Whether an autoantibody or antibody against TMEM247 could matter depends on whether native TMEM247 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM247 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM247 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM247. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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