Seroatlas · Human Serome Atlas

TMEM245

Transmembrane protein 245

Also known as: C9orf5, CG-2, TM245_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H330
Gene: TMEM245
Ensembl: ENSG00000106771
Chromosome: 9
Canonical length: 879 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

879 residues, UniProt reviewed canonical sequence.

>Q9H330|TMEM245
     1  MADGGGPKDA PSLRSSPGPA PRVPRAVGPS GGGGETPRTA ALALRFDKPI KQAFYNTGAV
    61  LFVCLCCGAA VLVYFILEAF LRPLLWAVLC GTFLHPFKSS LTRLGRHWLQ RLHRAHTPIV
   121  LAALLLPLCF VDYGVEALGE QALRRRRLLL LLGAGGPLLY GLYCLGSYLG VQVLLVHAAT
   181  LICRGLDYFS SLWIWTLVVG YVLTVSFKWN ASTERYLRAV SIPVWIILLF HLASLAGSWR
   241  IPVFLVIVFL MSVGTLYEKQ NGKESSGAEL PGQVISMAAS TLANLAISIT GYESSSEDQP
   301  STQPAEAVDR GESAPTLSTS PSPSSPSPTS PSPTLGRRRP EIGTFLRKKK TSDIYFVSLV
   361  WAIVVMQIWL NLWIVQLLPV PIAVWILKKL VIHFGVVDFL EKRYHVWWGI IESFLKERQG
   421  ALAPWPIVGL GKFLLKVDSK LWHWLNKKMI IWLEKMLDKI ISIFIIFLLV IGTLLLALLL
   481  TAKVHQESVH MIEVTSNLIN ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH
   541  KLHKILGDKV NNTAVIEKQV LELWDRLYHS WFVKNVTHSG RHKGQKLHVS RQNSWLGDIL
   601  DWQDIVSFVH ENIETFLSIL ESLWIVMSRN VSLLFTTVTT LLTILFYSGT ALLNFVLSLI
   661  IFLTTLFYLL SSSDEYYKPV KWVISLTPLS QPGPSSNIIG QSVEEAIRGV FDASLKMAGF
   721  YGLYTWLTHT MFGINIVFIP SALAAILGAV PFLGTYWAAV PAVLDLWLTQ GLGCKAILLL
   781  IFHLLPTYFV DTAIYSDISG GGHPYLTGLA VAGGAYYLGL EGAIIGPILL CILVVASNIY
   841  SAMLVSPTNS VPTPNQTPWP AQPQRTFRDI SEDLKSSVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM245 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 14
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 69 nTPM
parathyroid gland: 61 nTPM
adrenal gland: 45 nTPM
kidney: 43 nTPM
heart muscle: 40 nTPM
tongue: 37 nTPM

Single-cell type

adrenal cortex cells: 635 nCPM
alveolar cells type 2: 329 nCPM
distal convoluted tubule cells: 311 nCPM
thymic myoid cells: 296 nCPM
podocytes: 283 nCPM
proximal tubule cells: 269 nCPM

Immune cell

naive CD4 T-cell: 5.2 nTPM
basophil: 4.4 nTPM
T-reg: 4.4 nTPM
memory CD4 T-cell: 4 nTPM
naive CD8 T-cell: 3.6 nTPM
memory CD8 T-cell: 3.4 nTPM

Brain region

choroid plexus: 73 nTPM
hypothalamus: 49 nTPM
thalamus: 49 nTPM
spinal cord: 47 nTPM
midbrain: 45 nTPM
cerebral cortex: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.24
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein TqsA-like
AI-2E family transporter

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM245 as an antibody target. Whether an autoantibody or antibody against TMEM245 could matter depends on whether native TMEM245 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM245 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM245 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...