Seroatlas · Human Serome Atlas

TMEM244

Putative transmembrane protein 244

Also known as: bA174C7.4, C6orf191, TM244_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VVB8
Gene
TMEM244
Ensembl
ENSG00000203756
Chromosome
6
Canonical length
128 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q5VVB8|TMEM244
     1  MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF DFKTNPSWLN
    61  INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH VAITSTVMLE FPLTSHWWAA
   121  LGISKLLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM244 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • retina: 59 nTPM
  • pituitary gland: 1.6 nTPM
  • cerebral cortex: 1 nTPM
  • lymph node: 0.5 nTPM
  • spinal cord: 0.5 nTPM
  • hippocampal formation: 0.4 nTPM

Single-cell type

  • rod photoreceptor cells: 219 nCPM
  • cone photoreceptor cells: 110 nCPM
  • lactotrophs: 36 nCPM
  • podocytes: 23 nCPM
  • gonadotrophs: 21 nCPM
  • corticotrophs: 11 nCPM

Immune cell

  • T-reg: 1.6 nTPM
  • memory CD4 T-cell: 1.4 nTPM
  • gdT-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • white matter: 4 nTPM
  • cerebral cortex: 3.7 nTPM
  • hippocampal formation: 3.3 nTPM
  • basal ganglia: 2.6 nTPM
  • medulla oblongata: 2 nTPM
  • pons: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0.01
gnomAD missense Z
-0.37
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM244 as an antibody target. Whether an autoantibody or antibody against TMEM244 could matter depends on whether native TMEM244 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM244 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM244 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM244. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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