Seroatlas · Human Serome Atlas

TMEM243

Transmembrane protein 243

Also known as: C7orf23, MGC4175, MM-TRAG, TM243_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BU79
Gene
TMEM243
Ensembl
ENSG00000135185
Chromosome
7
Canonical length
118 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q9BU79|TMEM243
     1  MEDFATRTYG TSGLDNRPLF GETSAKDRII NLVVGSLTSL LILVTLISAF VFPQLPPKPL
    61  NIFFAVCISL SSITACILIY WYRQGDLEPK FRKLIYYIIF SIIMLCICAN LYFHDVGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM243 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 75 nTPM
  • thyroid gland: 67 nTPM
  • lymph node: 64 nTPM
  • lung: 50 nTPM
  • spleen: 42 nTPM
  • epididymis: 37 nTPM

Single-cell type

  • oocytes: 470 nCPM
  • b-cells: 241 nCPM
  • alveolar cells type 2: 225 nCPM
  • plasma cells: 209 nCPM
  • late primary spermatocytes: 207 nCPM
  • cytotrophoblasts: 147 nCPM

Immune cell

  • memory B-cell: 183 nTPM
  • naive B-cell: 172 nTPM
  • naive CD4 T-cell: 136 nTPM
  • plasmacytoid DC: 130 nTPM
  • naive CD8 T-cell: 96 nTPM
  • memory CD4 T-cell: 82 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • white matter: 17 nTPM
  • spinal cord: 17 nTPM
  • thalamus: 15 nTPM
  • medulla oblongata: 15 nTPM
  • basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF2678
  • Protein of unknown function (DUF2678)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM243 as an antibody target. Whether an autoantibody or antibody against TMEM243 could matter depends on whether native TMEM243 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM243 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM243 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM243. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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