Seroatlas · Human Serome Atlas

TMEM241

UDP-N-acetylglucosamine transporter TMEM241

Also known as: C18orf45, FLJ44259, MGC11386, TM241_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q24JQ0
Gene: TMEM241
Ensembl: ENSG00000134490
Chromosome: 18
Canonical length: 296 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables UDP-N-acetylglucosamine transmembrane transporter activity. Involved in UDP-N-acetylglucosamine transmembrane transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q24JQ0|TMEM241
     1  MCVRRSLVGL TFCTCYLASY LTNKYVLSVL KFTYPTLFQG WQTLIGGLLL HVSWKLGWVE
    61  INSSSRSHVL VWLPASVLFV GIIYAGSRAL SRLAIPVFLT LHNVAEVIIC GYQKCFQKEK
   121  TSPAKICSAL LLLAAAGCLP FNDSQFNPDG YFWAIIHLLC VGAYKILQKS QKPSALSDID
   181  QQYLNYIFSV VLLAFASHPT GDLFSVLDFP FLYFYRFHGS CCASGFLGFF LMFSTVKLKN
   241  LLAPGQCAAW IFFAKIITAG LSILLFDAIL TSATTGCLLL GALGEALLVF SERKSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM241 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 2.7 nTPM
cerebral cortex: 2.5 nTPM
parathyroid gland: 2.3 nTPM
breast: 2.1 nTPM
placenta: 2.1 nTPM
rectum: 2.1 nTPM

Single-cell type

endometrial glandular cells: 389 nCPM
adipocytes: 190 nCPM
podocytes: 174 nCPM
fibro-adipogenic progenitors: 145 nCPM
melanocytes: 142 nCPM
salivary acinar cells: 130 nCPM

Immune cell

NK-cell: 6 nTPM
intermediate monocyte: 2.2 nTPM
naive B-cell: 2.2 nTPM
myeloid DC: 2 nTPM
MAIT T-cell: 1.3 nTPM
memory B-cell: 1.3 nTPM

Brain region

cerebral cortex: 6.4 nTPM
white matter: 5.1 nTPM
basal ganglia: 4.3 nTPM
choroid plexus: 4 nTPM
hippocampal formation: 3.8 nTPM
hypothalamus: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.1
DepMap dependency class: none

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Triose Phosphate/Phosphate Translocator

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM241 as an antibody target. Whether an autoantibody or antibody against TMEM241 could matter depends on whether native TMEM241 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM241 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM241 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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