Seroatlas · Human Serome Atlas

TMEM239

Transmembrane protein 239

Also known as: TM239_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WW34
Gene
TMEM239
Ensembl
ENSG00000198326
Chromosome
20
Canonical length
195 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q8WW34|TMEM239
     1  MRVGTWICLP GRPGRCRKQH DLGNCPEVPG IFKTLALSPG APDMMQQPRV ETDTIGAGEG
    61  PQQAVPWSAW VTRHGWVRWW VSHMPPSWIQ WWSTSNWRQP LQRLLWGLEG ILYLLLALML
   121  CHALFTTGSH LLSSLWPVVA AVWRHLLPAL LLLVLSALPA LLFTASFLLL FSTLLSLVGL
   181  LTSMTHPGDT QDLDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM239 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • testis: 36 nTPM
  • retina: 0.8 nTPM
  • epididymis: 0.2 nTPM
  • adipose tissue: 0.1 nTPM
  • endometrium: 0.1 nTPM
  • placenta: 0.1 nTPM

Single-cell type

  • late spermatids: 183 nCPM
  • early spermatids: 26 nCPM
  • epicardial cells: 2.3 nCPM
  • late primary spermatocytes: 1.3 nCPM
  • differentiating spermatogonia: 0.2 nCPM
  • epididymal basal cells: 0.2 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 0.5 nTPM
  • cerebellum: 0.4 nTPM
  • cerebral cortex: 0.4 nTPM
  • choroid plexus: 0.4 nTPM
  • thalamus: 0.4 nTPM
  • amygdala: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
-0.04
DepMap dependency class
selective

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 239
  • Transmembrane protein 239 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM239 as an antibody target. Whether an autoantibody or antibody against TMEM239 could matter depends on whether native TMEM239 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM239 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM239 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM239. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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