Seroatlas · Human Serome Atlas

TMEM238

Transmembrane protein 238

Also known as: TM238_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9JI98
Gene
TMEM238
Ensembl
ENSG00000233493
Chromosome
19
Canonical length
176 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>C9JI98|TMEM238
     1  MAAAPAVCAS QGSPPGAPSA PAAAPAPAAG LGRCRMALLL AVALDVAGMA ALLTGVFAQL
    61  QVRGRDFGDL LIYSGALLVF LSLLGWILWY TGNIEISRQE LERDYGLRPS ALARLARKLS
   121  RRWSAPAAAG QRPAPGSRRA RRAARAPPPP AAGSRRVRLQ LATLEAGPGA AGAGSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM238 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 21 nTPM
  • stomach: 16 nTPM
  • colon: 15 nTPM
  • salivary gland: 14 nTPM
  • liver: 14 nTPM
  • small intestine: 14 nTPM

Single-cell type

  • fallopian secretory cells: 284 nCPM
  • respiratory deuterosomal cells: 221 nCPM
  • respiratory secretory cells: 186 nCPM
  • pancreatic acinar cells: 180 nCPM
  • alveolar cells type 2: 178 nCPM
  • prostatic club cells: 167 nCPM

Immune cell

  • T-reg: 1.3 nTPM
  • MAIT T-cell: 1 nTPM
  • memory CD4 T-cell: 1 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • naive CD4 T-cell: 0.7 nTPM
  • memory B-cell: 0.6 nTPM

Brain region

  • choroid plexus: 7 nTPM
  • cerebellum: 5.6 nTPM
  • midbrain: 3 nTPM
  • medulla oblongata: 2.8 nTPM
  • cerebral cortex: 2.7 nTPM
  • pons: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0.29
gnomAD missense Z
0.7
DepMap mean gene effect
-0.09
DepMap dependency class
selective

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM238 as an antibody target. Whether an autoantibody or antibody against TMEM238 could matter depends on whether native TMEM238 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM238 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM238 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM238. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...