Seroatlas · Human Serome Atlas

TMEM236

Transmembrane protein 236

Also known as: bA162I21.2, bA16O1.2, FAM23A, FAM23B, TM236_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5W0B7
Gene
TMEM236
Ensembl
ENSG00000148483
Chromosome
10
Canonical length
351 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q5W0B7|TMEM236
     1  MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI ISCSIAYVAL
    61  VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP CLTFSIAVTE VQKSINGSAD
   121  VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR
   181  QSPENAASPQ ATNSTQVSQP SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW
   241  SFLLWSDTIE MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP
   301  FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM236 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 32 nTPM
  • duodenum: 21 nTPM
  • colon: 13 nTPM
  • rectum: 13 nTPM
  • appendix: 1.6 nTPM
  • placenta: 1.4 nTPM

Single-cell type

  • enterocytes: 239 nCPM
  • colonocytes: 142 nCPM
  • pancreatic islet cells: 129 nCPM
  • breast lactating cells: 114 nCPM
  • goblet cells: 99 nCPM
  • enteric transient amplifying cells: 64 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • neutrophil: 0.3 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • cerebellum: 5.4 nTPM
  • white matter: 4.7 nTPM
  • cerebral cortex: 4.6 nTPM
  • choroid plexus: 4.5 nTPM
  • basal ganglia: 4.2 nTPM
  • amygdala: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0.02
gnomAD missense Z
0.26
DepMap mean gene effect
0.2
DepMap dependency class
none

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterised protein family, FAM23-like, transmembrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM236 as an antibody target. Whether an autoantibody or antibody against TMEM236 could matter depends on whether native TMEM236 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM236 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM236 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM236. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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