Seroatlas · Human Serome Atlas

TMEM234

Transmembrane protein 234

Also known as: C1orf91, dJ622L5.7, FLJ90779, RP4-622L5, TM234_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WY98
Gene
TMEM234
Ensembl
ENSG00000160055
Chromosome
1
Canonical length
164 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q8WY98|TMEM234
     1  MAASLGQVLA LVLVAALWGG TQPLLKRASA GLQRVHEPTW AQQLLQEMKT LFLNTEYLMP
    61  FLLNQCGSLL YYLTLASTDL TLAVPICNSL AIIFTLIVGK ALGEDIGGKR AVAGMVLTVI
   121  GISLCITSSV PWTAELQLHG KGQLQTLSQK CKREASGTQS ERFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM234 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 12 nTPM
  • thyroid gland: 12 nTPM
  • pituitary gland: 11 nTPM
  • ovary: 9.4 nTPM
  • kidney: 9.2 nTPM
  • esophagus: 8.6 nTPM

Single-cell type

  • late spermatids: 86 nCPM
  • esophageal apical cells: 55 nCPM
  • ependymal cells: 41 nCPM
  • respiratory ciliated cells: 40 nCPM
  • epididymal principal cells: 37 nCPM
  • epididymal efferent duct ciliated cells: 37 nCPM

Immune cell

  • neutrophil: 38 nTPM
  • basophil: 28 nTPM
  • eosinophil: 20 nTPM
  • intermediate monocyte: 15 nTPM
  • classical monocyte: 14 nTPM
  • myeloid DC: 13 nTPM

Brain region

  • choroid plexus: 10 nTPM
  • midbrain: 9.1 nTPM
  • medulla oblongata: 8.9 nTPM
  • hypothalamus: 8.1 nTPM
  • pons: 7.6 nTPM
  • cerebral cortex: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0
gnomAD missense Z
0.29
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM234 as an antibody target. Whether an autoantibody or antibody against TMEM234 could matter depends on whether native TMEM234 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM234 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM234 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM234. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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