Seroatlas · Human Serome Atlas

TMEM232

Transmembrane protein 232

Also known as: FLJ43080, TM232_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9JQI7
Gene
TMEM232
Ensembl
ENSG00000186952
Chromosome
5
Canonical length
657 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility and spermatid cytoplasm removal during spermiation of flagellated sperm. Predicted to act upstream of or within maintenance of protein complex location. Predicted to be located in membrane. Predicted to be active in outer dense fiber. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>C9JQI7|TMEM232
     1  MNMPVNKSPM INTCGGISSP YHEELWKLNF QHLSGERGHK SRPTFSITKE FILRFNQTQN
    61  SKEKEELLEL ARKIILRCKR KLGLKTLGSG RHVHLPAAWT EVIYLAQCKG EIQDESLNML
   121  YASLDHASFD YDHLPALFFV AESVLYRLCC DASLKTYLYS VEIKLAKIGY LVFLRLFIFF
   181  LHGHLESFKQ HLLRLQPYLY ALSFSGASYH KYPNIFSNVQ FILKASEIIG KRELRSESIF
   241  RPVEDKKRYE NTDSDMGGYE INHLLWHCVA AWSCVQNNSP QLNNVLEHLV FHKTQLQKKC
   301  WLDSVLALLV LGEAAKLNMA CLKALMDVVR DFVSSIMSVQ NQEESCKVDD FSWAWNVVYI
   361  YTVILAEICL YAATSDLRKT ALIGFCHCKS SQKNILYLDK SVPPELKETS ILSLLEYFSS
   421  KMSENCDQVV WTGYYGLVYN LVKISWELQG DEEQDGLRNM IWQTLQKTKD YEEDVRIQNA
   481  INIAQAELND PTDPFTRYST NISSNVGEEV FSKYIGWRIA NTLSKLFFPP IEAHFLPLKK
   541  PSIKKDQTKY PNKKLESVKK QVLHFTVREH PSVSEIPMFP YPDFFTKADK ELAKIIDHHW
   601  QEELKIREKE DAICKAQELK DKKLAEKNHF QEVMKKREEK LHKQTKPYEL PYRKEVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM232 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • testis: 16 nTPM
  • fallopian tube: 14 nTPM
  • thyroid gland: 3.5 nTPM
  • kidney: 3.4 nTPM
  • retina: 3.3 nTPM
  • choroid plexus: 3.2 nTPM

Single-cell type

  • ependymal cells: 3,598 nCPM
  • respiratory ciliated cells: 1,965 nCPM
  • choroid plexus epithelial cells: 1,197 nCPM
  • endometrial ciliated cells: 930 nCPM
  • fallopian tube ciliated cells: 866 nCPM
  • epididymal efferent duct ciliated cells: 591 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 23 nTPM
  • midbrain: 23 nTPM
  • medulla oblongata: 20 nTPM
  • spinal cord: 17 nTPM
  • white matter: 16 nTPM
  • pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 232
  • Transmembrane protein family 232

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM232 as an antibody target. Whether an autoantibody or antibody against TMEM232 could matter depends on whether native TMEM232 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM232 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM232 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM232. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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