Seroatlas · Human Serome Atlas

TMEM229B

Transmembrane protein 229B

Also known as: C14orf83, FLJ33387, T229B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBD8
Gene: TMEM229B
Ensembl: ENSG00000198133
Chromosome: 14
Canonical length: 167 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to act upstream of or within macrophage activation and response to bacterium. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q8NBD8|TMEM229B
     1  MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL FIYGTSILIV
    61  ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA CPWDYSQFDF DFMGLITLEY
   121  AVPWFCGALI MEQFIIRNTL RLRFDKDAEP GEPSGALALA NGHVKTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM229B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 25 nTPM
adrenal gland: 14 nTPM
cerebral cortex: 11 nTPM
parathyroid gland: 11 nTPM
duodenum: 10 nTPM
hippocampal formation: 9.9 nTPM

Single-cell type

cone photoreceptor cells: 89 nCPM
thyrotrophs: 66 nCPM
oligodendrocyte progenitor cells: 51 nCPM
epididymal principal cells: 48 nCPM
late spermatids: 48 nCPM
corticotrophs: 39 nCPM

Immune cell

gdT-cell: 6.9 nTPM
eosinophil: 6.3 nTPM
MAIT T-cell: 6.1 nTPM
memory CD8 T-cell: 5.4 nTPM
intermediate monocyte: 4.8 nTPM
naive CD8 T-cell: 4.6 nTPM

Brain region

pons: 42 nTPM
cerebellum: 36 nTPM
medulla oblongata: 28 nTPM
cerebral cortex: 25 nTPM
thalamus: 24 nTPM
midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0.13
gnomAD missense Z: 1.69
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Putative ABC-transporter type IV CmpB/TMEM229
Putative ABC-transporter type IV

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM229B as an antibody target. Whether an autoantibody or antibody against TMEM229B could matter depends on whether native TMEM229B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM229B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM229B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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