Seroatlas · Human Serome Atlas

TMEM225B

Transmembrane protein 225B

Also known as: T225B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DP42
Gene: TMEM225B
Ensembl: ENSG00000244219
Chromosome: 7
Canonical length: 221 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>P0DP42|TMEM225B
     1  MLTLEDKDMK GFSWAIVPAL TSLGYLIILV VSIFPFWVRL TNEESHEVFF SGLFENCFNA
    61  KCWKPRPLSI YIILGRVFLL SAVFLAFVTT FIMMPFASEF FPRTWKQNFV LACISFFTGA
   121  CAFLALVLHA LEIKALRMKL GPLQFSVLWP YYVLGFGIFL FIVAGTICLI QEMVCPCWHL
   181  LSTSQSMEED HGSLYLDNLE SLGGEPSSVQ KETQVTAETV I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM225B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 132 nTPM

Expression across tissuesHPA

Tissue

testis: 132 nTPM
skin: 3.8 nTPM
adipose tissue: 3.4 nTPM
epididymis: 3.3 nTPM
kidney: 3.1 nTPM
breast: 3 nTPM

Single-cell type

late primary spermatocytes: 1,154 nCPM
early spermatids: 260 nCPM
late spermatids: 197 nCPM
early primary spermatocytes: 137 nCPM
differentiating spermatogonia: 7.9 nCPM
epididymal basal cells: 7 nCPM

Immune cell

naive B-cell: 2.2 nTPM
naive CD8 T-cell: 1.4 nTPM
plasmacytoid DC: 1.4 nTPM
eosinophil: 1.3 nTPM
NK-cell: 1.3 nTPM
MAIT T-cell: 1.1 nTPM

Brain region

white matter: 3 nTPM
medulla oblongata: 2.6 nTPM
cerebral cortex: 2.3 nTPM
hypothalamus: 2.3 nTPM
basal ganglia: 2.2 nTPM
pons: 2.2 nTPM

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM225B as an antibody target. Whether an autoantibody or antibody against TMEM225B could matter depends on whether native TMEM225B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM225B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM225B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...