Seroatlas · Human Serome Atlas

TMEM222

Transmembrane protein 222

Also known as: C1orf160, DKFZP564D0478, TM222_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0R3
Gene: TMEM222
Ensembl: ENSG00000186501
Chromosome: 1
Canonical length: 208 aa
Protein class: Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location: Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

Located in dendrite. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q9H0R3|TMEM222
     1  MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS RFPYCVVWTP
    61  IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG KPAKYWKLDP AQVYASGPNA
   121  WDTAVHDASE EYKHRMHNLC CDNCHSHVAL ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS
   181  VGAFVKTWLP FILLLGIILT VSLVFNLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM222 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 77 nTPM
hypothalamus: 54 nTPM
hippocampal formation: 53 nTPM
basal ganglia: 52 nTPM
cerebral cortex: 51 nTPM
amygdala: 50 nTPM

Single-cell type

late spermatids: 138 nCPM
esophageal apical cells: 102 nCPM
esophageal suprabasal cells: 69 nCPM
late primary spermatocytes: 57 nCPM
epididymal principal cells: 53 nCPM
esophageal basal cells: 51 nCPM

Immune cell

neutrophil: 57 nTPM
basophil: 38 nTPM
memory B-cell: 38 nTPM
T-reg: 38 nTPM
non-classical monocyte: 36 nTPM
gdT-cell: 33 nTPM

Brain region

hypothalamus: 49 nTPM
midbrain: 48 nTPM
thalamus: 47 nTPM
pons: 43 nTPM
medulla oblongata: 42 nTPM
amygdala: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM222.

Disease | AllUniProt

Conditions TMEM222 is implicated in, by any mechanism.

Neurodevelopmental disorder with motor and speech delay and behavioral abnormalities (NEDMOSBA) MIM:619470

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with motor and speech delay and behavioral abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

TMEM222/RTE1
RTE1-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM222 as an antibody target. Whether an autoantibody or antibody against TMEM222 could matter depends on whether native TMEM222 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM222 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM222 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...