Seroatlas · Human Serome Atlas

TMEM219

Insulin-like growth factor-binding protein 3 receptor

Also known as: IGFBP-3R, TM219_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XT9
Gene: TMEM219
Ensembl: ENSG00000149932
Chromosome: 16
Canonical length: 240 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in apoptotic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q86XT9|TMEM219
     1  MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS PDIPQDWVSF
    61  LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR NKTRTFQATV LGSQMGLKGS
   121  SAGQLVLITA RVTTERTAGT CLYFSAVPGI LPSSQPPISC SEEGAGNATL SPRMGEECVS
   181  VWSHEGLVLT KLLTSEELAL CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM219 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 302 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 302 nTPM
amygdala: 251 nTPM
basal ganglia: 235 nTPM
midbrain: 225 nTPM
spinal cord: 225 nTPM
liver: 204 nTPM

Single-cell type

late spermatids: 831 nCPM
enterocytes: 595 nCPM
platelets: 514 nCPM
esophageal apical cells: 417 nCPM
epididymal principal cells: 386 nCPM
extravillous trophoblasts: 328 nCPM

Immune cell

basophil: 474 nTPM
eosinophil: 452 nTPM
classical monocyte: 334 nTPM
total PBMC: 328 nTPM
plasmacytoid DC: 299 nTPM
myeloid DC: 275 nTPM

Brain region

basal ganglia: 133 nTPM
spinal cord: 129 nTPM
medulla oblongata: 128 nTPM
thalamus: 127 nTPM
choroid plexus: 119 nTPM
amygdala: 114 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM219 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM219 as an antibody target. Whether an autoantibody or antibody against TMEM219 could matter depends on whether native TMEM219 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM219 is annotated at the cell surface, where native TMEM219 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM219 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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